182540-M

Aromatase Inhibitor I

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

• Sinonimo/i: Aromatase Inhibitor I, 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
• Formula empirica (notazione di Hill): C₁₇H₁₁N₃O₄
• Numero CAS: 331684-05-0
• Peso molecolare: 321.29
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 25 mg/mL
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC₅₀ = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.

A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC₅₀ = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).

Azioni biochim/fisiol

Primary Target
P450 arom.

Target IC₅₀: 40 nM against P450arom

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Recanatini, M., et al. 2001. J. Med. Chem.44, 672.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable