14-902-M

AMPK (α2, β1, γ1) Protein, active, 10 µg

Active, recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.

• Codice UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Livello qualitativo: 100
• Ricombinante: expressed in E. coli
• Nome Commerciale: Upstate^®
• Attività specifica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• PM: M_w 30 kDa (AMPKß1); M_w 38 kDa (AMPKγ1); M_w 63 kDa (AMPKα2)
• Purificato mediante: (Ni²⁺/NTA-agarose)
• Reattività contro le specie: human
• Produttore/marchio commerciale: Upstate^®
• tecniche: activity assay: suitable (kinase)
• Numero d’accesso: (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ); NM_006252
• N° accesso NCBI: NM_002733; NM_006252; NM_006253
• N° accesso UniProt: P54619; P54646; P54646, Q9Y478, P54619; Q9Y478
• Malattie correlate: diabetes; obesity; metabolic disorders
• Informazioni sul gene: human ... PRKAA2(5563) , PRKAB1(5563)

Descrizione

Descrizione generale

Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.

Applicazioni

Research Category
Metabolism

Apoptosis & Cancer

Research Sub Category
Diabetes

Obesity

Metabolic Disorders

Azioni biochim/fisiol

Protein Target: AMPK (α2, β1, γ1)

Target Sub-Family: CAMK

Confezionamento

Also available in 10 μg size and in bulk

Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.

Qualità

Routinely evaluated by phosphorylation of substrate peptide

Descrizione del bersaglio

AMPK (α2, β1, γ1)

Stato fisico

Cobalt-agarose

Stoccaggio e stabilità

6 months at -70°C

Altre note

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classi di pericolo: Skin Sens. 1
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°C): Not applicable