04-151

Anti-IFNAR-1 Antibody, clone MARI-5A3

clone MARI-5A3, from mouse

• Sinonimo/i: interferon (alpha, beta and omega) receptor 1, beta-type antiviral protein, alpha-type antiviral protein, Type I interferon receptor 1, Cytokine receptor family 2 member 1, interferon-beta receptor 1, Cytokine receptor class-II member 1, IFN-alpha-REC, i
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: MARI-5A3, monoclonal
• Reattività contro le specie: mouse
• tecniche: flow cytometry: suitable; immunoprecipitation (IP): suitable; neutralization: suitable; western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_034638
• N° accesso UniProt: P33896
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Ifnar1(15975)

Descrizione

Descrizione generale

Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.

Specificità

This antibody recognizes the extracellular domain of IFNAR-1.

Immunogeno

Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.

Applicazioni

Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.

Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

Qualità

Evaluated by Flow Cytometry in BALB/c splenocytes.

Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.

Descrizione del bersaglio

63 kDa calculated

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable