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D-045

Supelco

Doxylamine succinate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Formula empirica (notazione di Hill):
C21H28N2O5
Numero CAS:
562-10-7
Peso molecolare:
388.46
Numero CE:
200-659-6
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

300

Stato

liquid

Caratteristiche

Snap-N-Spike®/Snap-N-Shoot®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

1.0 mg/mL in methanol (as free base)

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

applicazioni

pharmaceutical (small molecule)

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2

InChI

1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
KBAUFVUYFNWQFM-UHFFFAOYSA-N

Informazioni sul gene

human ... HRH1(3269)

Descrizione generale

Doxylamine is a member of the ethanolamine class of antihistamines and is the most effective over-the-counter (OTC) sedative in the US. This Snap-N-Spike® Reference Solution is applicable to use in LC/MS or GC/MS applications for clinical toxicology or forensic analysis.

Applicazioni


  • Quality assessment of doxylamine succinate: A chemometric approach was applied for quality assessment of doxylamine succinate with its degradation product, using predictive models based on UV-spectrophotometric data, highlighting its utility in ensuring the integrity of pharmaceutical formulations (Abd El-Hadi et al., 2022).

  • Analysis in over-the-counter medications: Doxylamine succinate was analyzed as part of a quaternary mixture in cold medications, utilizing a sequential spectrophotometric resolution approach, indicating its role in multi-component pharmaceutical analysis (Kelani et al., 2023).

  • LC-MS/MS method for plasma levels: A sensitive LC-MS/MS method was developed for determining doxylamine levels in human plasma, demonstrating its application in pharmacokinetic studies and bioequivalence assessments (Fu et al., 2022).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes,Central nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

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J Y Renault et al.
Toxicology and applied pharmacology, 130(2), 177-187 (1995-02-01)
Inhibition of chondrogenesis in limb bud cell micromass cultures has been proposed as a short-term teratogen detection test. Validation studies were performed by testing large series of reference compounds and comparing their teratogenic potential with their ability to inhibit chondrogenesis;
Ashutosh Pathak et al.
Journal of AOAC International, 91(5), 1059-1069 (2008-11-05)
Three simple, rapid, and accurate methods, i.e., the derivative ratio spectra-zero-crossing method (method I), double divisor-ratio spectra derivative method (method II), and column reversed-phase high-performance liquid chromatographic (RP-HPLC) method (method III) were developed for the simultaneous determination of doxylamine succinate
C L Holder et al.
Journal of analytical toxicology, 11(3), 113-121 (1987-05-01)
Elimination and metabolic profiles of doxylamine and its nonconjugated metabolites were determined after the oral administration of [14C]-doxylamine succinate (13.3 mg/kg and 133 mg/kg doses) to male and female Fischer 344 rats. Total urine and fecal recovery of the administered
Andries Pelser et al.
Biopharmaceutics & drug disposition, 23(6), 239-244 (2002-09-06)
The intranasal route of administration provides a potential useful way of administering a range of systemic drugs. In order to assess the feasibility of this approach for the treatment of nausea and vomiting, doxylamine succinate was studied in rats for
A E Rudenko et al.
Likars'ka sprava, (2)(2), 55-59 (2003-05-31)
A positive result has been obtained in treating sleep disorders in patients with chronic vascular affections of the brain with using the drugs donormyl and sonnate-KM [symbol: see text]. Donormyl is recommended for use in sleep disturbances (not very prolonged
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