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870608H

Avanti

4-HNE-dimethylacetal

Avanti Research™ - A Croda Brand 870608H, hexane solution

Sinonimo/i:

(E)-4R-hydroxynonenal-dimethylacetal (Each vial contains 6.8mg which yields ~5.2mg 4-HNE after deprotection)

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About This Item

Formula empirica (notazione di Hill):
C11H22O3
Numero CAS:
119009-01-7
Peso molecolare:
202.29
Codice UNSPSC:
12352211
NACRES:
NA.25

Forma fisica

hexane solution

Confezionamento

pkg of 1 × 1 mL (870608H-5mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 870608H

Concentrazione

6.8 mg/mL (870608H-5mg)

Tipo di lipide

phosphoglycerides
bioactive lipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CCCCC[C@@H](O)/C=C/C(OC)OC

Descrizione generale

4-Hydroxynonenal (4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the compound during use. It can be easily converted to 4-HNE in the presence of acid.

Confezionamento

2 mL Amber Glass Sealed Ampule (870608H-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Avvertenze

Danger

Classi di pericolo

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

Organi bersaglio

Central nervous system, Nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

-14.8 °F - closed cup

Punto d’infiammabilità (°C)

-26.0 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Kamelija Zarkovic
Molecular aspects of medicine, 24(4-5), 293-303 (2003-08-02)
The development of oxidative stress, in which production of highly reactive oxygen species (ROS) overwhelms antioxidant defenses, is a feature of many neurological diseases: ischemic, inflammatory, metabolic and degenerative. Oxidative stress is increasingly implicated in a number of neurodegenerative disorders
Rajendra Sharma et al.
European journal of biochemistry, 271(9), 1690-1701 (2004-04-21)
4-Hydroxy-2-trans-nonenal (4-HNE), one of the major end products of lipid peroxidation, has been shown to induce apoptosis in a variety of cell lines. It appears to modulate signaling processes in more than one way because it has been suggested to
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
N Zarković et al.
Life sciences, 65(18-19), 1901-1904 (1999-11-27)
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and
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