700125P
Avanti
DMHCA
Avanti Research™ - A Croda Brand 700125P, powder
Sinonimo/i:
N,N-dimethyl-3β-hydroxycholenamide
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About This Item
Formula empirica (notazione di Hill):
C26H43NO2
Numero CAS:
Peso molecolare:
401.63
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25
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Saggio
>99% (TLC)
Stato
powder
Confezionamento
pkg of 1 × 5 mg (700125P-5mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 700125P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Descrizione generale
N,N-dimethyl-3β-hydroxy-cholenamide (DMHCA) is a potent steroidal liver X receptor (LXR) ligand in vitro and in vivo. It is used to treat atherosclerosis.
Applicazioni
DMHCA has been used as LXR activator to treat retinal endothelial cells in order to activate the sirtuin 1- liver X receptors (SIRT1-LXR) pathway.
It may be used as 3β-hydroxysterol-Δ24-reductase (DHCR24) inhibitor.
Azioni biochim/fisiol
N,N-dimethyl-3β-hydroxycholenamide (DHMCA) halts cholesterol biosynthesis by inhibiting 3β-hydroxysterol-Δ24-reductase (DHCR24) enzyme. It may serve as a therapeutic agent for treating atherosclerosis, age-related macular degeneration and diabetic retinopathy.
DMHCA (N,N-dimethyl-3β-hydroxycholenamide) is a synthetic oxysterol and is an agonist for liver X receptors (LXR). It promotes cholesterol transport, expression of adenosine triphosphate (ATP) binding cassette transporters. DMHCA suppresses the proinflammatory cytokines stimulation, induced by oxysterol.
Confezionamento
5 mL Amber Glass Screw Cap Vial (700125P-5mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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Certificati d'analisi (COA)
Lot/Batch Number
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor.
Quinet E M, et al.
Journal of Lipid Research, 45(10), 1929-1942 (2004)
The mechanism of diabetic retinopathy pathogenesis unifying key lipid regulators, sirtuin 1 and liver X receptor
Hammer SS, et al.
EBioMedicine, 22, 181-190 (2017)
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
Scoles DR, et al.
Gynecologic Oncology, 116(1), 109-116 (2010)
Synthetic LXR agonist attenuates plaque formation in apoE-/-mice without inducing liver steatosis and hypertriglyceridemia
Kratzer A, et al.
Journal of Lipid Research, 50(2), 312-326 (2009)
Nicole El-Darzi et al.
Frontiers in pharmacology, 9, 827-827 (2018-08-10)
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis. Herein, DMHCA was evaluated for its retinal effects on normal C57BL/6J and Cyp27a1-/-Cyp46a1-/- mice; the latter having higher retinal
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