QBD10273

Fmoc-N-amido-dPEG^®₈-acid

>95% (HPLC)

• Sinonimo/i: Fmoc-N-amido-PEG₈-COOH, Fmoc-N-amido-PEG₈-acid, Fmoc-NH-PEG₈-acid, Fmoc-PEG-acid
• Formula empirica (notazione di Hill): C₃₄H₄₉NO₁₂
• Peso molecolare: 663.75
• Numero MDL: MFCD11041143
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Saggio: >95% (HPLC)
• Stato: solid or viscous liquid
• Impiego in reazioni chimiche: reaction type: Pegylations
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: N(CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: VYXGUCLTEWCVRY-UHFFFAOYSA-N

Descrizione

Caratteristiche e vantaggi

Fmoc-N-amido-dPEG₈-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEG_n-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

Note legali

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable