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Key Documents

Altri documenti

B8154

Sigma-Aldrich

Baccatin III

≥95% (HPLC)

Sinonimo/i:

O-De[(2R,3S)-3-(Benzoylamino)-2-hydroxy-3-phenylpropanoyl]paclitaxel

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About This Item

Formula empirica (notazione di Hill):
C31H38O11
Numero CAS:
27548-93-2
Peso molecolare:
586.63
Numero MDL:
MFCD00153921
Codice UNSPSC:
12352005
ID PubChem:
57653960
NACRES:
NA.22

Saggio

≥95% (HPLC)

Forma fisica

powder

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](O)C(C)=C1C5(C)C

InChI

1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1
OVMSOCFBDVBLFW-VHLOTGQHSA-N

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Categorie correlate

Applicazioni

Precursor to paclitaxel

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H315,H319,H335,H340,H350

Classi di pericolo

Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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3,4-Dimethoxybenzoyl chloride 98%

Sigma-Aldrich

258040

3,4-Dimethoxybenzoyl chloride

Protocatechuic acid ethyl ester 97%

Sigma-Aldrich

E24859

Protocatechuic acid ethyl ester

Paclitaxel, Taxus sp. Antitumor and antileukemic agent isolated from the bark of the yew tree.

Sigma-Aldrich

580555

Paclitaxel, Taxus sp.

Paclitaxel United States Pharmacopeia (USP) Reference Standard

USP

1491332

Paclitaxel

D-(−)-Quinic acid 98%

Sigma-Aldrich

138622

D-(−)-Quinic acid

Paclitaxel from semisynthetic, ≥98%

Sigma-Aldrich

T7191

Paclitaxel

Chia-Hsiang Hwang et al.
Phytotherapy research : PTR, 26(4), 528-534 (2011-09-15)
7,7''-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from the needles of Taxus × media cv. Hicksii, was evaluated for its antiproliferative and antineoplastic effects in three human cancer cell lines. Interestingly, DMGF caused cell death via different pathways in different cancer cells.
Takayuki Doi et al.
Chemistry, an Asian journal, 1(3), 370-383 (2007-04-19)
A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D
Jared T Spletstoser et al.
Bioorganic & medicinal chemistry letters, 16(3), 495-498 (2005-11-18)
A single-site modification of paclitaxel analogs at the C10 position on the baccatin III core that reduces interaction with P-glycoprotein in bovine brain microvessel endothelial cells is described. Modification and derivatization of the C10 position were carried out using a
Bing-Juan Li et al.
Nature communications, 8, 15544-15544 (2017-05-19)
The natural concentration of the anticancer drug Taxol is about 0.02% in yew trees, whereas that of its analogue 7-β-xylosyl-10-deacetyltaxol is up to 0.5%. While this compound is not an intermediate in Taxol biosynthetic route, it can be converted into
Elizabeth M Heider et al.
Physical chemistry chemical physics : PCCP, 9(46), 6083-6097 (2008-01-03)
The three-dimensional structure of a unique polymorph of the anticancer drug paclitaxel (Taxol) is established using solid state NMR (SSNMR) tensor ((13)C & (15)N) and heteronuclear correlation ((1)H-(13)C) data. The polymorph has two molecules per asymmetric unit (Z' = 2)
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