934232

Pomalidomide-2,6-diazaspiro[3.3]heptane

≥95.0%

• Sinonimo/i: 1H-Isoindole-1,3(2H)-dione, 5-(2,6-diazaspiro[3.3]hept-2-yl)-2-(2,6-dioxo-3-piperidinyl), 5-(2,6-Diazaspiro[3.3]heptan-2-yl)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
• Formula empirica (notazione di Hill): C₁₈H₁₈N₄O₄
• Numero CAS: 2226301-50-2
• Peso molecolare: 354.36
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• ligand: pomalidomide
• Livello qualitativo: 100
• Saggio: ≥95.0%
• Stato: powder or crystals
• Colore: off-white to light yellow
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CC5(CNC5)C4)C=C31)=O
• InChI: 1S/C18H18N4O4/c23-14-4-3-13(15(24)20-14)22-16(25)11-2-1-10(5-12(11)17(22)26)21-8-18(9-21)6-19-7-18/h1-2,5,13,19H,3-4,6-9H2,(H,20,23,24); ZJRIIJGHSAJWMI-UHFFFAOYSA-N

Descrizione

Applicazioni

Pomalidomide-2,6-diazaspiro[3.3]heptane Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight:
Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Note legali

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H360D
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable