932612
NanoFabTx™ Biotin Lipid Mix
for synthesis of biotin-functionalized liposomes for small molecule delivery
Sinonimo/i:
Biotin-PEG-DSPE, Cholesterol, HSPC, PEG-DSPE
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About This Item
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Livello qualitativo
Temperatura di conservazione
−20°C
Applicazioni
NanoFabTx™ Biotin Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of biotin-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with biotin groups using extrusion and microfluidics are also included. The synthesized biotin-functionalized liposomes enable 1) selectively targeting cells which overexpress avidin-receptors (i.e. HeLa cells) and 2) the conjugation of avidin-tagged antibodies or proteins (i.e. Streptavidin) to the liposomes surface for immunotherapy applications and multi-targeting or multi-type cargo delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with biotin groups using extrusion and microfluidics are also included. The synthesized biotin-functionalized liposomes enable 1) selectively targeting cells which overexpress avidin-receptors (i.e. HeLa cells) and 2) the conjugation of avidin-tagged antibodies or proteins (i.e. Streptavidin) to the liposomes surface for immunotherapy applications and multi-targeting or multi-type cargo delivery.
Caratteristiche e vantaggi
- A ready-to-use nanoformulation lipid blend for the synthesis of biotin-functionalized liposomes
- Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible liposomes
- Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
- Lipid mix optimized for avidin-tagged protein or antibody conjugation and small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
For more information, please refer to the protocol under the Protocol section of this page.
Note legali
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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Eliana B Souto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128, 27-35 (2018-11-26)
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