930466
HMP-alkyne
≥95%
Sinonimo/i:
4-Hydroxy-3-(hydroxymethyl)-N-(prop-2-yn-1-yl)benzenesulfonamide
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About This Item
Formula empirica (notazione di Hill):
C10H11NO4S
Peso molecolare:
241.26
Numero MDL:
Codice UNSPSC:
12352101
NACRES:
NA.22
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Descrizione
Application: Chemoproteomics
Livello qualitativo
Saggio
≥95%
Stato
powder or chunks
Temperatura di conservazione
−20°C
Stringa SMILE
OCC1=C(O)C=CC(S(NCC#C)(=O)=O)=C1
InChI
1S/C10H11NO4S/c1-2-5-11-16(14,15)9-3-4-10(13)8(6-9)7-12/h1,3-4,6,11-13H,5,7H2
FINAVIKBDSCNKL-UHFFFAOYSA-N
Applicazioni
HMP-alkyne is a probe that can be used to photochemically label tryptophans. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)
Altre note
Profiling the proteome-wide selectivity of diverse electrophiles
A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells
A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile
Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity
A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes
Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells
A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs
Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile
Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity
Prodotti correlati
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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