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4-Diphenylmethoxy-1-methylpiperidine hydrochloride

Name: 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
Brand: ALDRICH

95%

Sinonimo/i:

4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride

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About This Item

Formula empirica (notazione di Hill):

C₁₉H₂₃NO · HCl

Numero CAS:

132-18-3

Peso molecolare:

317.85

Numero CE:

205-049-3

Numero MDL:

MFCD00012835

Codice UNSPSC:

12352100

ID PubChem:

24856946

NACRES:

NA.22

Prodotti consigliati

Slide 1 of 1

1 of 1

Sigma-Aldrich

C8546

Cellulase from Trichoderma reesei ATCC 26921

Livello qualitativo

100

Saggio

95%

Punto di fusione

203-205 °C (lit.)

Gruppo funzionale

ether
phenyl

Stringa SMILE

Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3

InChI

1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H
LPRLDRXGWKXRMQ-UHFFFAOYSA-N

Informazioni sul gene

human ... HRH1(3269)

Categorie correlate

Building block eterociclici

Descrizione generale

4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine.

Applicazioni

4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease.

Pittogrammi

GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties.

Gennady B Lapa et al.

European journal of pharmacology, 506(3), 237-240 (2005-01-04)

Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse

Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.

M Vasudevan et al.

Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)

A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH

Effects of H1 antihistamines on canine nasal vascular and airway resistances.

M A Lung et al.

Rhinology, 25(2), 95-100 (1987-06-01)

The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses

Determination of diphenylpyraline in plasma and urine by high-performance liquid chromatography.

K O Ebete et al.

Journal of chromatography. B, Biomedical applications, 677(2), 319-323 (1996-03-03)

A rapid, reliable and specific reversed-phase high-performance liquid chromatographic procedure is described for the determination of diphenylpyraline hydrochloride at nanogram concentrations in plasma and urine. After extraction of the drug with n-pentane-2-propanol (50:1) from alkalinized samples, the organic extract was

Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry.

Chika Hasegawa et al.

Rapid communications in mass spectrometry : RCM, 20(4), 537-543 (2006-01-19)

Ten antihistamine drugs, diphenhydramine, orphenadrine, chlorpheniramine, diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded monolithic silica gel was fixed. Human plasma (0.1

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