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146358

Sigma-Aldrich

1-Ethyl-2-pyrrolidone

98%

Sinonimo/i:

NEP

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About This Item

Formula empirica (notazione di Hill):
C6H11NO
Numero CAS:
2687-91-4
Peso molecolare:
113.16
Beilstein:
107971
Numero CE:
220-250-6
Numero MDL:
MFCD00003199
Codice UNSPSC:
12352100
ID PubChem:
24848778
NACRES:
NA.22

Livello qualitativo

100

Saggio

98%

Forma fisica

liquid

Indice di rifrazione

n20/D 1.465 (lit.)

P. eboll.

97 °C/20 mmHg (lit.)

Densità

0.992 g/mL at 25 °C (lit.)

Stringa SMILE

CCN1CCCC1=O

InChI

1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3
ZFPGARUNNKGOBB-UHFFFAOYSA-N

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Descrizione generale

1-Ethyl-2-pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.

Applicazioni

1-Ethyl-2-pyrrolidone was used to modify coir fiber (from Cocos nucifera) by photocuring.

Pittogrammi

Health hazardCorrosion
GHS08,GHS05

Avvertenze

Danger

Indicazioni di pericolo

H318,H360D

Classi di pericolo

Eye Dam. 1 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

195.8 °F - Pensky-Martens closed cup

Punto d’infiammabilità (°C)

91 °C - Pensky-Martens closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
STBK5568
STBK0377
STBJ0978
STBH7138
STBG3952V

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1-metil-2-pirrolidinone United States Pharmacopeia (USP) Reference Standard

USP

1437202

1-metil-2-pirrolidinone

2-Pyrrolidinone ≥99%

Sigma-Aldrich

240338

2-Pyrrolidinone

1,5-Dimethyl-2-pyrrolidinone 95%

Sigma-Aldrich

D184101

1,5-Dimethyl-2-pyrrolidinone

2-Hydroxy-N,N-dimethylpropanamide

Sigma-Aldrich

CDS021721

2-Hydroxy-N,N-dimethylpropanamide

Effect of penetration enhancers (pyrrolidone derivatives) on multilamellar liposomes of stratum corneum lipid: a study by UV spectroscopy and differential scanning calorimetry.
Kim C-K, et al.
International Journal of Pharmaceutics, 95(1), 43-50 (1993)
Takeshi Katsuda et al.
Scientific reports, 3, 1197-1197 (2013-02-05)
Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ) in the brain because of an imbalance between Aβ production and clearance. Neprilysin (NEP) is the most important Aβ-degrading enzyme in the brain. Thus, researchers have explored virus-mediated
Ajeet Kaushik et al.
Scientific reports, 7, 45663-45663 (2017-04-05)
In this research, we demonstrate cell uptake of magneto-electric nanoparticles (MENPs) through nanoelectroporation (NEP) using alternating current (ac)-magnetic field stimulation. Uptake of MENPs was confirmed using focused-ion-beam assisted transmission electron microscopy (FIB-TEM) and validated by a numerical simulation model. The
Effect of Pretreatment with Ultraviolet Radiation on the Physicomechanical Properties of Photocured Coir (Cocos nucifera) Fiber with 1-Ethyl-2-Pyrrolidone (1-E-2-P) Monomer.
Khan MA, et al.
Polymer-Plastics Technology and Engineering, 45(4), 487-494 (2006)
Xiaolei Zhu et al.
Aging cell, 16(5), 1073-1082 (2017-08-05)
The accumulation and deposition of beta-amyloid (Aβ) is a key neuropathological hallmark of Alzheimer's disease (AD). Histone deacetylases (HDACs) are promising therapeutic targets for the treatment of AD, while the specific HDAC isoforms associated with cognitive improvement are poorly understood.
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