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Merck

RRM2B

ribonucleotide reductase M2 B (TP53 inducible)

Sinonimi:
MTDPS8A, MTDPS8B, P53R2
Specie:
ID UniProtKB:
ID gene:
  • Human(50484) Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
  • Mouse(382985) ribonucleotide reductase M2 B (TP53 inducible)
  • Rat(299976) ribonucleotide reductase M2 B (TP53 inducible)
  • cow(528960) ribonucleotide reductase M2 B (TP53 inducible)
  • sheep(101123639) ribonucleotide reductase M2 B (TP53 inducible)
  • naked mole-rat(101718446) ribonucleotide reductase M2 B (TP53 inducible)
  • domestic guinea pig(100715485) ribonucleotide reductase M2 B (TP53 inducible)
  • Zebrafish(368909) ribonucleotide reductase M2 b
  • chicken(420253) ribonucleotide reductase M2 B (TP53 inducible)
  • Horse(100062030) ribonucleotide reductase M2 B (TP53 inducible)
  • domestic cat(101099777) ribonucleotide reductase M2 B (TP53 inducible)
  • dog(481988) ribonucleotide reductase M2 B (TP53 inducible)

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-RRM2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
Anti-P53R2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-RRM2B antibody produced in mouse, clone 6C1, ascites fluid,
Reattività con
human
Applicazione
ELISA
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Idrossiurea, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Idrossiurea, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Idrossiurea, British Pharmacopoeia (BP) Reference Standard,
Specie
human
Idrossiurea, 98%, powder,
Specie
human
Gemcitabine hydrochloride, ≥98% (HPLC),
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human RRM2B,
Specie
human