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Merck

GRIA4

glutamate receptor, ionotropic, AMPA 4

Sinonimi:
GLUR4, GLUR4C, GLURD, GluA4
Specie:
ID UniProtKB:
ID gene:
  • Human(2893) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
  • Mouse(14802) glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Rat(29629) glutamate receptor, ionotropic, AMPA 4
  • chicken(396137) glutamate receptor, ionotropic, AMPA 4
  • dog(489427) glutamate receptor, ionotropic, AMPA 4
  • Horse(100061561) glutamate receptor, ionotropic, AMPA 4
  • cow(529904) glutamate receptor, ionotrophic, AMPA 4
  • domestic cat(101087003) glutamate receptor, ionotropic, AMPA 4
  • domestic guinea pig(100728256) glutamate receptor, ionotropic, AMPA 4
  • naked mole-rat(101698538) glutamate receptor, ionotropic, AMPA 4
  • sheep(443274) glutamate receptor, ionotropic, AMPA 4

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide, ≥98% (HPLC), solid,
Specie
human
Cyclothiazide, ,
Specie
human, rat
(±)-AMPA, solid,
Specie
rat
(S)-AMPA, ≥97%,
Specie
mouse, human, rat
Kainic acid monohydrate, ≥99% (TLC),
Specie
human, mouse, rat

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
CX546, ≥98% (HPLC), solid,
Specie
human
Piracetam, ,
Specie
human, rat
Cyclothiazide, ,
Specie
human, rat
Kainic acid monohydrate, ≥99% (TLC),
Specie
human, mouse, rat
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
GYKI 52466 hydrochloride, solid,
Specie
human
Piracetam, ,
Specie
human, rat
CNQX disodium salt hydrate, ≥98% (HPLC), solid,
Specie
human
NBQX disodium salt hydrate, ≥98% (HPLC),
Specie
human
(±)-AMPA, solid,
Specie
rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anticorpo anti-recettore per il glutammato 4, Chemicon®, from rabbit,
Reattività con
mouse, rat
Applicazione
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Gria4 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
Anti-GLUR4 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
Anti-GRIA4 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
bovine, human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot

Small Molecule - Blocker

N° Catalogo
Descrizione
Specie
Cyclothiazide, ,
Specie
human, rat
Kynurenic acid, ≥98%,
Specie
rat, human
Topiramate, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
Topiramate, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human

Small Molecule - Mixed Agonist/Antagonist

N° Catalogo
Descrizione
Specie
Cyclothiazide, ,
Specie
human, rat
(±)-AMPA, solid,
Specie
rat
Kainic acid monohydrate, ≥99% (TLC),
Specie
human, mouse, rat
Acido L-glutammico, ReagentPlus®, ≥99% (HPLC),
Specie
rat, human
Acido L-glutammico, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Specie
rat, human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human GRIA4,
Specie
human
MISSION® esiRNA, targeting mouse Gria4,
Specie
mouse