Passa al contenuto
Merck

CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Sinonimi:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Specie:
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...Più
ID UniProtKB:
P46527, Q16307, Q5U0H2, Q9BUS6
ID gene:
  • Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
  • Mouse(12576) cyclin-dependent kinase inhibitor 1B
  • Rat(83571) cyclin-dependent kinase inhibitor 1B
  • chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
SAB4504200
Anti-phospho-p27 Kip1 (pThr198) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
WH0001027M1
Monoclonal Anti-CDKN1B antibody produced in mouse, clone 4B4-E6, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
06-996
Anti-phospho-Kip1 (Thr187) Antibody, Upstate®, from rabbit,
Reattività con
human, mouse, rat
Applicazione
western blot
06-445
Anti-Kip1 (p27) Antibody, Upstate®, from rabbit,
Reattività con
human, rabbit, rat
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
HPA059086
Anti-CDKN1B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
R7772
Roscovitine, ≥98% (TLC),
Specie
human, mouse, rat
O0886
Olomoucine, ≥98% (HPLC),
Specie
human, rat

Proteins

N° Catalogo
Descrizione
Specie
SRP5109
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human
23-024-M
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EMU028461
MISSION® esiRNA, targeting mouse Cdkn1b,
Specie
mouse
EHU025821
MISSION® esiRNA, targeting human CDKN1B,
Specie
human