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1461003

USP

Acide nicotinique

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Acide 3-picolinique, Acide pyridine-3-carboxylique, Facteur de prévention de la pellagre

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About This Item

Formule empirique (notation de Hill):
C6H5NO2
Numéro CAS:
59-67-6
Poids moléculaire :
123.11
Numéro Beilstein :
109591
Numéro MDL:
MFCD00006391
Code UNSPSC :
41116107
ID de substance PubChem :
329750552
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

nicotinic acid

Fabricant/nom de marque

USP

Technique(s)

HPLC: suitable

Pf

236-239 °C (lit.)

Solubilité

ethanol: 12.5 g/L at 25 °C
water: soluble 180 g/L at 20 °C

Densité

1.473 g/cm3 at 25 °C

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

Clé InChI

PVNIIMVLHYAWGP-UHFFFAOYSA-N

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Niacin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Niacin Tablets
  • Niacin Injection
  • Niacin Extended-Release Tablets
  • Inositol Niacinate
  • Niacinamide
  • Water-Soluble Vitamins Capsules

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

379.4 °F - closed cup

Point d'éclair (°C)

193 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Les clients ont également consulté

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Nicotinic Acid A component of coenzymes NAD+ and NADP+.

Millipore

481918

Nicotinic Acid

(−)-Riboflavine United States Pharmacopeia (USP) Reference Standard

USP

1603006

(−)-Riboflavine

Acide nicotinique European Pharmacopoeia (EP) Reference Standard

Y0001995

Acide nicotinique

Nicotinic acid for synthesis

Sigma-Aldrich

8.18714

Nicotinic acid

Vaijinath S Kamanna et al.
Current opinion in lipidology, 24(3), 239-245 (2013-04-27)
This review focuses on the current understanding of the physiological mechanisms of action of niacin on lipid metabolism and atherosclerosis. Emerging findings indicate that niacin decreases hepatic triglyceride synthesis and subsequent VLDL/LDL secretion by directly and noncompetitively inhibiting hepatocyte diacylglycerol
James B Kirkland
Mutation research, 733(1-2), 14-20 (2011-12-06)
Through its involvement in over 400 NAD(P)-dependent reactions, niacin status has the potential to influence every area of metabolism. Niacin deficiency has been linked to genomic instability largely through impaired function of the poly ADP-ribose polymerase (PARP) family of enzymes.
Matilda Florentin et al.
Current vascular pharmacology, 9(4), 385-400 (2011-02-15)
Treatment with statins has significantly reduced cardiovascular morbidity and mortality, an effect attributed to both the low-density lipoprotein cholesterol (LDL-C) lowering capacity and the pleiotropic actions of these drugs. However, residual risk remains even after intense LDL-C lowering. Therefore, additional
Janet E Digby et al.
Current opinion in lipidology, 20(4), 321-326 (2009-06-06)
Nicotinic acid is the most potent treatment clinically available for lowering LDL cholesterol and VLDL cholesterol and raising HDL cholesterol. The strong inverse relationship between coronary heart disease risk and HDL cholesterol at all levels of LDL cholesterol has, therefore
E T Bodor et al.
British journal of pharmacology, 153 Suppl 1, S68-S75 (2007-11-27)
Nicotinic acid has been used for decades to treat dyslipidaemic states. In particular its ability to raise the plasma HDL cholesterol concentration has led to an increased interest in its pharmacological potential. The clinical use of nicotinic acid is somewhat
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