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1362103

USP

Levofloxacin

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Levofloxacin hemihydrate

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About This Item

Formule empirique (notation de Hill):
C18H20FN3O4 · 0.5H2O
Numéro CAS:
138199-71-0
Poids moléculaire :
370.38
Numéro MDL:
MFCD07772024
Code UNSPSC :
41116107
ID de substance PubChem :
329750045
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

levofloxacin

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

O.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(O)=O.C[C@H]5COc6c(N7CCN(C)CC7)c(F)cc8C(=O)C(=CN5c68)C(O)=O

InChI

1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1

Clé InChI

SUIQUYDRLGGZOL-RCWTXCDDSA-N

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Catégories apparentées

Application

Levofloxacin USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Levofloxacin Tablets
  • Levofloxacin Oral Solution

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

1362114

Levofloxacin Related Compound A, United States Pharmacopeia (USP) Reference Standard

1362125

Levofloxacin Related Compound B, United States Pharmacopeia (USP) Reference Standard

1362136

Levofloxacin Related Compound C, United States Pharmacopeia (USP) Reference Standard

1362169

Levofloxacin Related Compound F, United States Pharmacopeia (USP) Reference Standard

1362158

Levofloxacin Related Compound E, United States Pharmacopeia (USP) Reference Standard

Y0002085

Levofloxacin hemihydrate, European Pharmacopoeia (EP) Reference Standard

Y0002084

Levofloxacin impurity F, European Pharmacopoeia (EP) Reference Standard

Y0002089

Levofloxacin for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR2229

Levofloxacin Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2230

Levofloxacin Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H317,H334

Classification des risques

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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R Davis et al.
Drugs, 47(4), 677-700 (1994-04-01)
Levofloxacin, an oral fluoroquinolone antibacterial agent, is the optical S-(-) isomer of ofloxacin. In vitro it is generally twice as potent as ofloxacin. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes. Drug
Analysis and Standardization of Levofloxacin Substance.
Sedova, M. K., et al.
Pharmaceutical Chemistry Journal, 47.11, 620-626 (2014)
Kyung Eun Han et al.
American journal of ophthalmology, 157(6), 1144-1150 (2014-02-25)
To evaluate dry eye and meibomian gland dysfunction after cataract surgery. Prospective observational case series. We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores
Lixian He et al.
Anti-cancer drugs, 26(3), 359-362 (2014-12-09)
This pilot study assesses the safety and efficacy of once-daily, oral levofloxacin monotherapy in Chinese patients with low-risk febrile neutropenia. In this prospective, single-arm, open-label, multicenter clinical trial, 46 adult Chinese patients with solid tumors and low-risk febrile neutropenia were
Sabine Schuster et al.
Antimicrobial agents and chemotherapy, 58(11), 6870-6878 (2014-09-04)
Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activity in
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