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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Synonyme(s) :

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Formule empirique (notation de Hill):
C10H10N2O2S
Numéro CAS:
327036-89-5
Poids moléculaire :
222.26
Numéro MDL:
MFCD04973552
Code UNSPSC :
12352200
ID de substance PubChem :
329826879
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

needles

Conditions de stockage

protect from light

Couleur

white

Pf

63-64.4 °C

Solubilité

DMSO: >10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Clé InChI

JDSJDASOXWCHPN-UHFFFAOYSA-N

Application

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Actions biochimiques/physiologiques

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Caractéristiques et avantages

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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