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SRP5111

p33ING1, His tagged human

Name: p33ING1, His tagged human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

ING1, p24ING1c, p33, p33ING1b, p47, p47ING1a

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About This Item

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.32

Produit recombinant

expressed in baculovirus infected Sf9 cells

Essai

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Poids mol.

~38 kDa

Numéro d'accès NCBI

NM_198219

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... ING1(3621)

Description générale

p33ING1 displays characteristics of a tumour suppressor protein and can induce cell growth arrest and apoptosis. p33ING1 is a nuclear protein and acute expression of p33 ING1 inhibits cell growth. p33ING1 physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Mutation of p33ING1 gene occurs in neuroblastoma cells and reduced expression is observed in some breast cancer cell lines. It has been proposed that p33ING1 can act as a potent growth regulator in normal and in established cells and plays a role as a candidate tumour suppressor gene whose inactivation may contribute to the development of cancers.

Forme physique

Supplied in 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Pictogrammes

GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H315,H319,H360D

Conseils de prudence

P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Classification des risques

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Q199-1

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Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation

Garkavtsev

Nature genetics, 23(3), 373-373 (1999-11-05)

Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.

Frauke Goeman et al.

Molecular and cellular biology, 25(1), 422-431 (2004-12-17)

ING1 was identified as an inhibitor of growth and has been described as a tumor suppressor. Furthermore, the expression of ING1 is induced in senescent cells and antisense ING1 extends the proliferative life span of primary human fibroblasts. Cooperation of

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