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SRP5075

Sigma-Aldrich

PTPN2, active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

PTPT, TCELLPTP, TCPTP

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in E. coli

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Activité spécifique

6928-9372 nmol/min·mg

Poids mol.

~69 kDa

Numéro d'accès NCBI

NM_080422

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... PTPN2(5771)

Description générale

Research Area: Cell Signaling
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.

Actions biochimiques/physiologiques

Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) regulates interferon signaling and the endoplasmic reticulum stress response in pancreatic β-cells during autoimmune diabetes. It serves as a crucial prognostic marker that influences the progression of pancreatic adenocarcinoma (PAAD) by activating the JAK-STAT signaling pathway. Silencing PTPN2 leads to a significant reduction in PAAD cell growth, migration, and invasion, while also triggering cell cycle arrest and apoptosis in PAAD cells.

Forme physique

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Tetsuya Yamamoto et al.
Biochemical and biophysical research communications, 297(4), 811-817 (2002-10-03)
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway. In this study, we examined
Sanjeev Gupta et al.
FEBS letters, 532(1-2), 61-66 (2002-12-03)
PTP-S2/TC45 is a nuclear protein tyrosine phosphatase, which induces p53-dependent apoptosis. Here we show that the p53 protein level increased in MCF-7 cells in response to PTP-S2 overexpression. PTP-S2-induced p53 protein was transcriptionally active and it could activate caspase-1 gene

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