SML3388

Vortioxetine hydrobromide

≥98% (HPLC)

• Synonyme(s) : 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, Lu AA21004 HBr, Lu AA21004 hydrobromide, Vortioxetine HBr
• Formule empirique (notation de Hill): C₁₈H₂₂N₂S·HBr
• Numéro CAS: 960203-27-4
• Poids moléculaire : 379.36
• Numéro MDL: MFCD22383961
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• InChI: 1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
• Clé InChI: VNGRUFUIHGGOOM-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Vortioxetine (Lu AA21004) is an orally active, multimodal serotonergic compound with high affinity toward human 5-HT1A (Ki = 15 nM), 5-HT1B (Ki = 33 nM), 5-HT1D (Ki = 54 nM), 5-HT3A (Ki = 3.7 nM), 5-HT7 (Ki = 19 nM), noradrenergic β1 (Ki = 46 nM) receptors, and serotonin (5-HT) transporter (SERT Ki = 1.6 nM). Vortioxetine exhibits in vivo psychotropic efficacy by exerting antagonist activity against 5-HT-1D/3A/7, agonist activity on 5-HT1A, partial agonist activity on 5-HT1B, as well as potent SERT inhibitory activity.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H361d,H373,H410
• Conseils de prudence: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
• Organes cibles: Kidney
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable