SML1162

5-Fluoro-1-propargyl-uracil

≥98% (HPLC)

• Synonyme(s) : 1-Propargyl-5-fluorouracil, 5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
• Formule empirique (notation de Hill): C₇H₅FN₂O₂
• Numéro CAS: 69849-33-8
• Poids moléculaire : 168.13
• Numéro MDL: MFCD18364451
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825692
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 1 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1C(F)=CN(CC#C)C(N1)=O
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• Clé InChI: GMCOGJQJFDQZCP-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil iside a tumor that has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable