SML1005

NSC 617145

≥98% (HPLC)

• Synonyme(s) : (2,3-Propandiyl-bis(2,3-dichloro)maleimide, 1,1′-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-Pyrrole-2,5-dione, NSC-617145, SID 487795
• Formule empirique (notation de Hill): C₁₃H₁₀Cl₄N₂O₄
• Numéro CAS: 203115-63-3
• Poids moléculaire : 400.04
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to light brown
• Solubilité: DMSO: 3 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• InChI: 1S/C13H10Cl4N2O4/c1-13(2,3-18-9(20)5(14)6(15)10(18)21)4-19-11(22)7(16)8(17)12(19)23/h3-4H2,1-2H3
• Clé InChI: PCOXPBOKDABARQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

NSC 617145 has an IC₅₀ value of 230nM.

NSC 617145 is a potent and cell-permeable inhibitor of Werner syndrome helicase (WRN) that causes accumulation of double-strand breaks (DSB) and chromosomal abnormalities in cancer cells.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable