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SML0421

Sigma-Aldrich

SB265610

≥98% (HPLC)

Synonyme(s) :

1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea, N-(2-Bromophenyl)-N′-(7-cyano-1H-benzotriazol-4-yl)urea, SB 265610

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About This Item

Formule empirique (notation de Hill):
C14H9BrN6O
Numéro CAS:
211096-49-0
Poids moléculaire :
357.16
Numéro MDL:
MFCD09971124
Code UNSPSC :
51111800
ID de substance PubChem :
329825416
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to light brown

Solubilité

DMSO: 15 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23

InChI

1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)

Clé InChI

SEDUMQWZEOMXSO-UHFFFAOYSA-N

Application

SB265610 has been used:
  • as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
  • as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
  • as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain

Actions biochimiques/physiologiques

SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.

Caractéristiques et avantages

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
015M4704V
102M4722V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

François Binet et al.
Science (New York, N.Y.), 369(6506) (2020-08-21)
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we
Tao Zhang et al.
European journal of immunology, 48(6), 1059-1073 (2018-02-21)
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found
Jing Zhao et al.
Scientific reports, 7(1), 16128-16128 (2017-11-25)
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed
Julia Esser-von Bieren et al.
PLoS pathogens, 11(3), e1004778-e1004778 (2015-03-26)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptive multicellular parasites might
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