Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

Voir toute la documentation

SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

Synonyme(s) :

JRF 12, N2,N4-dibenzylquinazoline-2,4-diamine

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill) :
C22H20N4
Numéro CAS:
177355-84-9
Poids moléculaire :
340.42
Numéro MDL:
MFCD03691820
Code UNSPSC :
12352200
ID de substance PubChem :
329825101
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

room temp

Chaîne SMILES 

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

Clé InChI

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Catégories apparentées

Application

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Actions biochimiques/physiologiques

ATPase p97 inhibitor.
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
086M4751V
055M4726V
054M4715V
121M4713V
051M4738V

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 6

1 of 6

Cordycepin from Cordyceps militaris

Sigma-Aldrich

C3394

Cordycepin

MHY1485 ≥95% (HPLC)

Sigma-Aldrich

SML0810

MHY1485

Thapsigargine ≥98% (HPLC), solid film

Sigma-Aldrich

T9033

Thapsigargine

Importazole ≥98% (HPLC)

Sigma-Aldrich

SML0341

Importazole

Bréfeldine A from Penicillium brefeldianum, Ready Made Solution, 10 mg/mL in DMSO

Sigma-Aldrich

B5936

Bréfeldine A

Bréfeldine A from Penicillium brefeldianum, ≥99% (HPLC and TLC)

Sigma-Aldrich

B7651

Bréfeldine A

Holger W Auner et al.
PloS one, 8(9), e74415-e74415 (2013-09-27)
Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma cells (MMCs) have to deal with. Resistance of MMCs to proteasome inhibition has been linked to
Yongwang Zhong et al.
The Journal of biological chemistry, 287(33), 28057-28066 (2012-06-23)
Misfolded proteins in the endoplasmic reticulum (ER) are dislocated to the cytosol to be degraded by the proteasomes. Various plant and bacterial toxins and certain viruses hijack this dislocation pathway to exert their toxicity or to infect cells. In this
Angela McHugh et al.
The Journal of investigative dermatology, 140(6), 1154-1165 (2019-11-11)
We performed a small interfering RNA screen to identify targets for cutaneous squamous cell carcinoma (cSCC) therapy in the ubiquitin/ubiquitin-like system. We provide evidence for selective anti-cSCC activity of knockdown of the E3 ubiquitin ligase MARCH4, the ATPase p97/VCP, the
Shana D Hardy et al.
Oncotarget, 8(61), 103302-103314 (2017-12-22)
Processing bodies (P-bodies) are ribonucleoprotein complexes involved in post-transcriptional mRNA metabolism that accumulate in cells exposed to various stress stimuli. The treatment of mammary epithelial cells with transforming growth factor-beta (TGF-β), triggers epithelial-mesenchymal transition (EMT), and induces the formation of
Ajit Tiwari et al.
Scientific reports, 6, 38681-38681 (2016-12-09)
Caveolin-1 (Cav1) drives the formation of flask-shaped membrane invaginations known as caveolae that participate in signaling, clathrin-independent endocytosis and mechanotransduction. Overexpression or mutations of Cav1 can lead to its mistrafficking, including its accumulation in a perinuclear compartment previously identified as
Afficher tous les articles scientifiques apparentés

Articles

Autophagy in Cancer Promotes Therapeutic Resistance

We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique