Q3251

Quinacrine dihydrochloride

≥90%

• Synonyme(s) : 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• Formule empirique (notation de Hill): C₂₃H₃₀ClN₃O · 2HCl
• Numéro CAS: 69-05-6
• Poids moléculaire : 472.88
• Numéro Beilstein : 4834013
• Numéro CE : 200-700-8
• Numéro MDL: MFCD00012659
• Code UNSPSC : 12352101
• ID de substance PubChem : 24278192
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 100
• Pureté: ≥90%
• Forme: powder
• Pf: 257 °C
• Solubilité: H₂O: soluble, clear to hazy
• Auteur: Bayer
• Chaîne SMILES: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• Clé InChI: UDKVBVICMUEIKS-UHFFFAOYSA-N
• Informations sur le gène: human ... MAOA(4128) , MAOB(4129)

Description

Description générale

Quinacrine is an acridine derivative and a potent antimalarial agent.

Application

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Actions biochimiques/physiologiques

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

Caractéristiques et avantages

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves