PZ0221

PF-06439015 methanesulfonate salt

≥98% (HPLC)

• Synonyme(s) : 2R-(5-{6-Amino-5-[1R-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-ethoxy]-pyridin-3-yl}-4-methyl-thiazol-2-yl)-propane-1,2-diol methanesulfonate, PF-06439015 mesylate, PF-06439015 methanesulfonate
• Formule empirique (notation de Hill): C₂₂H₂₃FN₆O₃S · CH₃SO₃H
• Numéro CAS: 1565822-20-9
• Poids moléculaire : 566.63
• Numéro MDL: MFCD27978372
• Code UNSPSC : 12352200
• ID de substance PubChem : 329823778
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 15 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: OC[C@](O)(C)C(S1)=NC(C)=C1C2=CN=C(N)C(O[C@H](C)C3=C(N4N=CC=N4)C=CC(F)=C3)=C2.CS(O)(=O)=O
• InChI: 1S/C22H23FN6O3S.CH4O3S/c1-12-19(33-21(28-12)22(3,31)11-30)14-8-18(20(24)25-10-14)32-13(2)16-9-15(23)4-5-17(16)29-26-6-7-27-29;1-5(2,3)4/h4-10,13,30-31H,11H2,1-3H3,(H2,24,25);1H3,(H,2,3,4)/t13-,22-;/m1./s1
• Clé InChI: CVPQOLHPYNCJHK-RSUIGRPMSA-N

Description

Actions biochimiques/physiologiques

PF-06439015 is a potent and selective inihibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant to Crizotinib. PF-06439015 is potent across a broad panel of ALK mutant cell lines with an IC₅₀ of 6.6 nM for tumor growth inhibition in a crizotinib-resistant cell line (H3122-L1196M).

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable