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P3032

Sigma-Aldrich

Penicillin G sodium salt

powder, suitable for cell culture, BioReagent

Synonyme(s) :

Benzylpenicillin sodium salt

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About This Item

Formule empirique (notation de Hill):
C16H17N2NaO4S
Numéro CAS:
Poids moléculaire :
356.37
Numéro Beilstein :
3834217
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352207
eCl@ss :
34010400
ID de substance PubChem :
Nomenclature NACRES :
NA.76

product name

Penicillin G sodium salt, powder, BioReagent, suitable for cell culture

Gamme de produits

BioReagent

Forme

powder

Puissance

≥1477 units per mg

Technique(s)

cell culture | mammalian: suitable

Solubilité

H2O: 100 mg/mL

Spectre d'activité de l'antibiotique

Gram-positive bacteria

Mode d’action

cell wall synthesis | interferes

Température de stockage

2-8°C

Chaîne SMILES 

[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O

InChI

1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

Clé InChI

FCPVYOBCFFNJFS-LQDWTQKMSA-M

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Description générale

Chemical structure: ß-lactam
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.

Application

Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

Actions biochimiques/physiologiques

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Attention

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.

Autres remarques

1mu,10mu,25mu,100mu
Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin Keep in a dry place.

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Paul P Drury et al.
Neuropharmacology, 83, 62-70 (2014-04-15)
Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival
Ana Amaral et al.
Frontiers in veterinary science, 7, 582211-582211 (2020-11-17)
Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis. Cathepsin G (CAT), a protease present in NETs, is inhibited by
Fleury Augustin Nsole Biteghe et al.
Journal of photochemistry and photobiology. B, Biology, 211, 111982-111982 (2020-09-01)
Aberrant anti-cancer drug efflux mediated by membrane protein ABC transporters (ABCB5 and ABCG2) is thought to characterize melanoma heterogeneous chemoresistant populations, presumed to have unlimited proliferative and self-renewal abilities. Therefore, this study primarily aimed to investigate whether continuous exposure of
Maria Eugenia Sabatino et al.
Frontiers in cell and developmental biology, 7, 297-297 (2019-12-12)
Krüppel-like factor 6 (KLF6) is a transcription factor involved in the regulation of several cellular processes. Regarding its role in tumorigenesis, KLF6 is considered a tumor suppressor. Numerous reports demonstrate its frequent genomic loss or down-regulation, implying a functional inactivation
Shuang Zhou et al.
Biosensors & bioelectronics, 49, 99-104 (2013-06-01)
Regulatory restrictions on antibiotic residues in dairy products have resulted in the illegal addition of β-lactamase to lower antibiotic levels in milk in China. Here we demonstrate a fast, sensitive and convenient method based on enzyme thermistor (ET) for the

Articles

Inhibition of Cell Wall Biosynthesis by Antibiotics

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