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L7647

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

Type VI, lyophilized powder

Synonyme(s) :

Con A

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About This Item

Numéro CAS:
11028-71-0
Numéro CE :
234-258-2
Numéro MDL:
MFCD00071069
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

Canavalia ensiformis

Type

Type VI

Forme

lyophilized powder

Puissance

≤20 μg per mL agglutination activity

Impuretés

Carbohydrate, essentially free
 salt, essentially free

Solubilité

water: 1 % (w/v)

Température de stockage

−20°C

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Application

Concanavalin A from Canavalia ensiformis (Jack bean) has been used for developing zwitterion-immobilized molecularly imprinted polymers (ziMIPs) for protein crystallization. It has been also used in the preparation of protein loaded microgels to prevent enzymatic degradation of microgels for monitoring by confocal laser scanning microscope (CLSM).

Actions biochimiques/physiologiques

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Notes préparatoires

Highly purified by specific affinity chromatography.

Remarque sur l'analyse

Agglutination activity: Determined from serial dilutions of a 1 mg/mL solution (this activity is the lowest conc. to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C). Requires Type A Human Blood.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H317,H334,H361

Classification des risques

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Zwitterion-Immobilized Imprinted Polymers for Promoting the Crystallization of Proteins
Xing Y, et al.
Crystal Growth & Design, 15(10), 4932-4937 (2015)
Derivatization of epoxy-activated agarose with various carbohydrates for the preparation of stable and high-capacity affinity adsorbents: their use for affinity chromatography of carbohydrate-binding proteins.
I Matsumoto et al.
Analytical biochemistry, 116(1), 103-110 (1981-09-01)
Zuobing Zhang et al.
Biology, 9(5) (2020-05-30)
The Chinese soft-shelled turtle (Pelodiscus sinesis) is a widely cultured commercial species in East and Southeast Asian countries. The turtles frequently suffer from acute cold stress during farming in China. Stress-induced factor such as Interleukin-6 (IL6) is a multifunctional molecule
Chain and pore-blocking effects on matrix degradation in protein-loaded microgels
Widenbring R, et al.
Biomacromolecules, 15(10), 3671-3678 (2014)
Lindsay Kosack et al.
Scientific reports, 7(1), 11289-11289 (2017-09-14)
Lipid metabolism is increasingly being appreciated to affect immunoregulation, inflammation and pathology. In this study we found that mice infected with lymphocytic choriomeningitis virus (LCMV) exhibit global perturbations of circulating serum lipids. Mice lacking the lipid-sensing surface receptor triggering receptor
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