I4269

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonyme(s) : IL-4, Interleukin-4 human, hIL-4
• Numéro MDL: MFCD00151705
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• Source biologique: human
• Niveau de qualité: 200
• Produit recombinant: expressed in E. coli
• Essai: ≥98% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: ≤0.400 ng/mL EC₅₀
• Qualité: endotoxin tested
• Poids mol.: 14.9 kDa (containing 129 amino acid residues)
• Conditionnement: pkg of 5 and 50 μg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤1.000 EU/μg
• Couleur: white
• Numéro d'accès UniProt: P05112
• Température de stockage: −20°C
• Informations sur le gène: human ... IL4(3565) ; mouse ... IL4(3565)

Description

Description générale

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.^1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.³

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.⁴

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.⁵

Application

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

Forme physique

Lyophilized from a sterile filtered solution.

Remarque sur l'analyse

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable