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Autres documents

I1020

Sigma-Aldrich

Interleukin-4 from mouse

IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

mIL-4, Interleukin-4 human

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About This Item

Numéro MDL:
MFCD00166698
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

≥98% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.1-2.0 ng/mL ED50/EC50

Qualité

endotoxin tested

Poids mol.

~13.5 kDa

Conditionnement

pkg of 5 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

<0.1 EU/μg

Numéro d'accès UniProt

P07750

Température de stockage

−20°C

Informations sur le gène

mouse ... Il4(16189)

Application

Interleukin-4 from mouse has been used:
  • as a component of cell culture media for class switch recombination assay
  • to study its therapeutic benefits for mucosal healing
  • as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)

Actions biochimiques/physiologiques

Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.

Forme physique

Lyophilized, 0.2 μm filtered, with no additives.

Remarque sur l'analyse

The proliferative activity is tested in culture using mouse HT-2 cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

R Fernandez-Botran et al.
The Journal of experimental medicine, 164(2), 580-593 (1986-08-01)
T cell-derived supernatants (SN) that contain B cell-stimulatory factor 1 (BSF-1) and lack IL-2 promote the growth of the IL-2-dependent T cell line, HT-2, as well as three other clones or lines of T cells that can provide help to
Jun-ichi Shono et al.
Animal science journal = Nihon chikusan Gakkaiho, 84(11), 744-750 (2013-08-29)
Muscle damage induces massive macrophage infiltration of the injury site, in which activated pro-inflammatory and anti-inflammatory phenotypes (currently classified as M1 and M2, respectively) have been documented as distinct functional populations predominant at different times after the conventional acute injury
New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice
Silva JC, et al.
Advances in Wound Care (2019)
Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells
Sharba S, et al.
Virulence, 10(1), 97-117 (2019)
VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells
Khan AJ, et al.
Oncotarget, 9(40), 25833-25833 (2018)
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Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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