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H4014

Sigma-Aldrich

25-Hydroxycholecalciferol

≥98% (HPLC)

Synonyme(s) :

25-Hydroxyvitamin D3

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About This Item

Formule empirique (notation de Hill):
C27H44O2
Numéro CAS:
19356-17-3
Poids moléculaire :
400.64
Numéro CE :
242-990-9
Numéro MDL:
MFCD00867077
Code UNSPSC :
12352205
ID de substance PubChem :
24895612
Nomenclature NACRES :
NA.79

Niveau de qualité

200

Pureté

≥98% (HPLC)

Forme

powder

Technique(s)

HPLC: suitable

Couleur

white to off-white

Température de stockage

−20°C

Chaîne SMILES 

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

Clé InChI

JWUBBDSIWDLEOM-DTOXIADCSA-N

Informations sur le gène

human ... VDR(7421)

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Application


  • Immunoassay development 25-Hydroxycholecalciferol: An investigation into the safety and efficacy of 25-hydroxycholecalciferol produced with Saccharomyces cerevisiae for animal feed emphasized its potential application in developing immunoassays that monitor vitamin D levels in animals, providing a basis for similar applications in human diagnostics (EFSA Panel on Additives and Products, 2023).

Actions biochimiques/physiologiques

Ergocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two form of vitamin D which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301 + H311,H330,H372

Classification des risques

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

M Abboud et al.
Endocrinology, 154(9), 3022-3030 (2013-07-05)
Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In
Richard McKenzie et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 12(9), 1726-1737 (2013-06-29)
To clarify the relation between UV exposure and vitamin D status, 201 volunteers wore personal electronic UV dosimeters during daylight hours, to record their UV exposure over a 10 week period when ambient UV levels were significantly less than the
Julia Höbaus et al.
International journal of cancer, 133(6), 1380-1388 (2013-03-07)
In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). However, the underlying mechanism of CYP24A1 overexpression is poorly understood. In
Jerry Liu et al.
Food chemistry, 140(3), 432-435 (2013-04-23)
There is little information on the vitamin D content of Australian red meat or on the possible influence of latitude on this content. To determine the content of vitamin D3 and 25-hydroxy-vitamin D3 (25OHD3), lamb and beef were analysed from
Bianca Weinstock-Guttman et al.
Journal of neurology, neurosurgery, and psychiatry, 84(11), 1186-1191 (2013-04-19)
To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment
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