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GW20083F

Sigma-Aldrich

Anti-Human IgG (Fc specific) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Immunoglobulin G Fc

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About This Item

Numéro MDL:
MFCD00162436
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

chicken

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat, human, mouse

Fabricant/nom de marque

Genway 15-288-20083F

Technique(s)

western blot: suitable

Numéro d'accès UniProt

P01857

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... IGHG1(3500)

Immunogène

IgG Fc human native protein.

Application

Anti-Human IgG (Fc specific) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Ig γ-1 chain C region is a protein encoded by the IGHG1 gene in humans. Igγ-1 chain C region is present in human pancreatic cancer tissues and its expression is very low in adjacent noncancerous tissues. IGHG1 blockage leads to retarded tumor growth and improved survival. Its presence in pancreatic cancer cells might constitute an important element that is responsible for tumor cell proliferation and immune evasion mechanisms. IGHG1 is associated with prostate cancer and can inhibit cell viability leading to apoptosis. It may act as a potential target in prostate cancer gene therapy.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Judith Blaine
Methods in molecular biology (Clifton, N.J.), 2224, 123-132 (2021-02-20)
Proteinuria is a widely used marker of renal disease and is strongly associated with renal and cardiovascular outcomes. The molecular mechanisms underlying filtration of serum proteins through the glomerular filtration barrier (GFB) remain to be determined. Since the GFB is
Xiaoyan Li et al.
Pancreas, 40(5), 753-761 (2011-06-10)
To investigate the expression of Igγ-1 chain C region (IGHG1) in human pancreatic carcinomas and determine the biological function of IGHG1 expression in immune evasion mechanisms. Comparative proteomic analysis was used to detect the differential expression of IGHG1 in human
Bin Pan et al.
Molecular biology reports, 40(1), 27-33 (2012-11-03)
To investigate the immunoglobulin G (IgG) expression in prostate cancer cell lines and explore the effects of IGHG1 gene knockdown on PC3 cell growth and apoptosis. Flow cytometry, qPCR and western blot were used to demonstrate IgG expression in prostate
James Dylewski et al.
PloS one, 14(2), e0209732-e0209732 (2019-02-28)
Proteinuria is strongly associated with kidney disease progression but the mechanisms underlying podocyte handling of serum proteins such as albumin and IgG remain to be elucidated. We have previously shown that albumin and IgG are transcytosed by podocytes in vitro.

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