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SAB4200682

Sigma-Aldrich

Anti-Human IgG (Fc specific) antibody, Mouse monoclonal

clone GG-7, purified from hybridoma cell culture

Synonyme(s) :

Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Niveau de qualité

300

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

GG-7, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: suitable
immunofluorescence: suitable
indirect ELISA: 0.25-0.5 μg/mL using 5μg/mL human IgG for coating.

Isotype

IgG1

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Description générale

Monoclonal Anti-Human IgG (Fc specific) (mouse IgG1 isotype) is derived from the GG-7 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment.

Immunogène

Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads

Application

Monoclonal Anti-Human IgG (Fc specific) antibody has been used in:
  • ELISA
  • Imprint Immunofixation (IIF)
  • Immunofluorometric Assay (IFMA)
  • Hemagglutination (HA)
  • Hemagglutination Inhibition (HAI)
  • Particle Counting Immunoassay (PACIA)
  • detection of cytoplasmic IgG

Actions biochimiques/physiologiques

The crystallizable fragment (Fc) of IgG has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. IgG deficiencies are often associated with various diseases.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Jefferis R., et al.,
Annales De Biologie Clinique, 52, 57-65 (1994)
Wang L., et al.,
Hybridoma, 1, 293-302 (1982)
Papadea C. and Check IJ.
Critical Reviews in Clinical Laboratory Sciences, 27, 27-58 (1989)
Structure and function of human and murine receptors for IgG
Unkeless J C, et al.
Annual Review of Immunology, 6(1), 251-281 (1988)
C B Reimer et al.
Hybridoma, 3(3), 263-275 (1984-01-01)
Stable clones of 31 mouse hybridomas that produce monoclonal antibodies (MAbs) against human IgG antigenic determinants were obtained. The number of hybridomas of different specificity described are: 2 anti-IgG1 Fc, 1 anti-IgG2 Fc, 1 anti-IgG2 Fd, 2 anti-IgG3 Fc, 2

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