F7057
Folate Receptor 2 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonyme(s) :
FOLR2, Folate Receptor beta
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.56
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in CHO cells
Essai
≥95% (SDS-PAGE)
Forme
lyophilized
Impuretés
≤1.0 EU/μg endotoxin
Numéro d'accès UniProt
Application(s)
cell analysis
Température de stockage
−20°C
Informations sur le gène
human ... FOLR2(2350)
Application
Folate Receptor 2 has been used in studies of the treatment of rheumatoid arthritis (RA) with Methotrexate (MTX). These studies have focused on transport of MTX through folate receptor 2 in RA synovial macrophages.
Actions biochimiques/physiologiques
Folate Receptor 2 is a 38kDa protein that has a high affinity for folic acid and mediates 5-methyltetrahydrofolate to the inside of the cell.
Forme physique
Lyophilized from PBS
Reconstitution
Reconstitute at 100 μg/ mL in PBS
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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