C5366

Chlorisondamine diiodide

≥98% (HPLC), white, solid

• Synonyme(s) : 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
• Formule empirique (notation de Hill): C₁₄H₂₀Cl₄I₂N₂
• Numéro CAS: 96750-66-2
• Poids moléculaire : 611.94
• Numéro MDL: MFCD01074794
• Code UNSPSC : 12352116
• ID de substance PubChem : 24724443
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light
• Couleur: white
• Solubilité: H₂O: ≥2 mg/mL; DMSO: >20 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• Clé InChI: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

Description

Application

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

Actions biochimiques/physiologiques

Chlorisondamine diiodide mediates ganglionic and central blockade.

Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

Caractéristiques et avantages

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This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H400
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves