C4650
Cholestyramine resin
Synonyme(s) :
Colestyramine, Dowex 1X2 Cl--Form
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About This Item
Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
23151817
Nomenclature NACRES :
NA.56
Produits recommandés
Forme
powder
Technique(s)
activity assay: suitable
Matrice
polystyrene/divinylbenzene
pH
4—6
Capacité
~1.0 meq/g(dry)
Application
Cholestyramine resin has been used:
- as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
- to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
- in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)
Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.
Actions biochimiques/physiologiques
Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.
Autres remarques
Quartenary ammonium functional groups attached to cross-linked polystyrene
Informations légales
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
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Hepatology (Baltimore, Md.), 58(4), 1451-1460 (2013-05-21)
Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH) to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids (BAs), whose levels rise in the blood early after PH, stimulate both hepatocyte
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World journal of surgery, 37(3), 657-662 (2012-12-12)
The aim of the present study was to evaluate the efficacy of cholestyramine ointment (15 %) in reducing postoperative pain at rest and during defecation after open hemorrhoidectomy. A total of 91 patients with third and fourth degree hemorrhoids undergoing
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Journal of anxiety disorders, 26(2), 287-296 (2012-01-17)
In this study, the cost-effectiveness of three indicated anxiety prevention strategies was examined from a societal perspective. Children (aged 8-12) were recruited via primary schools, selecting children scoring as high-anxious on an anxiety screening questionnaire. Participating children and their parents
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