27840

Corticostérone

≥98.5% (HPLC)

• Synonyme(s) : 11β,21-dihydroxy-4-pregnène-3,20-dione, 11β,21-dihydroxyprogestérone, 4-pregnène-11β,21-diol-3,20-dione, Composé B de Kendall, Substance H de Reichstein
• Formule empirique (notation de Hill) : C₂₁H₃₀O₄
• Numéro CAS: 50-22-6
• Poids moléculaire : 346.46
• Beilstein: 2339601
• Numéro CE : 200-019-6
• Numéro MDL: MFCD00037715
• Code UNSPSC : 12352211
• ID de substance PubChem : 57648276
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: ≥98.5% (HPLC)
• Forme: powder or crystals
• Activité optique: [α]20/D +223±3°, c = 1% in ethanol
• Pf: 179-183 °C (lit.); 179-183 °C
• Groupe fonctionnel: ketone
• Chaîne SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• Clé InChI: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
• Informations sur le gène: human ... EBP(10682) , SERPINA6(866) ; rat ... Ar(24208) , Nr3c1(24413)

Description

Description générale

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Application

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Actions biochimiques/physiologiques

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Notes préparatoires

Corticosterone is soluble in chloroform and ethanol.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves