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C0742

Sigma-Aldrich

CKI-7 dihydrochloride

≥98% (HPLC), solid, CK1 inhibitor

Synonyme(s) :

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride

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About This Item

Formule empirique (notation de Hill):
C11H12ClN3O2S · 2HCl
Numéro CAS:
1177141-67-1
Poids moléculaire :
358.67
Numéro MDL:
MFCD00897689
Code UNSPSC :
12352200
ID de substance PubChem :
24724430
Nomenclature NACRES :
NA.77

product name

CKI-7 dihydrochloride, ≥98% (HPLC), solid

Pureté

≥98% (HPLC)

Forme

solid

Conditions de stockage

desiccated

Couleur

white to light tan

Solubilité

H2O: >5 mg/mL

Température de stockage

−20°C

Chaîne SMILES 

Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12

InChI

1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H

Clé InChI

JUAVTXYOCISSSL-UHFFFAOYSA-N

Actions biochimiques/physiologiques

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.

Attention

Material is hygroscopic

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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