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Key Documents

Autres documents

C001

Sigma-Aldrich

Acetylethylcholine mustard hydrochloride

>97% (GC), powder

Synonyme(s) :

Acetyl AF-64

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About This Item

Formule empirique (notation de Hill):
C8H16ClNO2 · HCl
Numéro CAS:
103994-00-9
Poids moléculaire :
230.13
Numéro MDL:
MFCD00055153
Code UNSPSC :
12352200
ID de substance PubChem :
329774756
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>97% (GC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white

Pf

78-81  °C

Solubilité

H2O: >5 mg/mL
ethanol: soluble
methanol: soluble

Température de stockage

−20°C

Chaîne SMILES 

Cl[H].CCN(CCCl)CCOC(C)=O

InChI

1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H

Clé InChI

CHWPASAPXMNLKO-UHFFFAOYSA-N

Application

Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.

Actions biochimiques/physiologiques

Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.

Attention

Extremely hygroscopic.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3

Organes cibles

Nervous system, Respiratory system

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

204.8 °F - closed cup

Point d'éclair (°C)

96 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Pennapa Chonpathompikunlert et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(3), 798-802 (2009-12-26)
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Surapon N Charoensook et al.
Integrative biology : quantitative biosciences from nano to macro, 9(12), 956-967 (2017-11-24)
In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synaptogenesis, synaptic maintenance, and pathogenesis of neurodegenerative diseases. Many models have previously been developed using a variety of cell sources for skeletal muscle and
Yvonne L Dorland et al.
Scientific reports, 9(1), 14401-14401 (2019-10-09)
Culture expanded mesenchymal stromal cells (MSCs) are being extensively studied for therapeutic applications, including treatment of graft-versus-host disease, osteogenesis imperfecta and for enhancing engraftment of hematopoietic stem cells after transplantation. Thus far, clinical trials have shown that the therapeutic efficiency

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