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Key Documents

B2929

Sigma-Aldrich

B-Lymphocyte Chemoattractant human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonyme(s) :

B-Cell Attracting Chemokine 1, BCA-1, BLC

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About This Item

Numéro MDL:
MFCD01867020
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

200

Produit recombinant

expressed in E. coli

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.1000 μg/mL

Poids mol.

apparent mol wt 8.7 kDa by SDS-PAGE (reducing)

Conditionnement

pkg of 25 μg

Conditions de stockage

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

O43927

Température de stockage

−20°C

Informations sur le gène

human ... CXCL13(10563)

Catégories apparentées

Actions biochimiques/physiologiques

BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils.
BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils. Its specific receptor BLR1 is a G protein-coupled receptor originally isolated from Burkitt′s lymphoma cells. Among cells of the hematopoietic lineages, the expression of BRL1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.
The biological activity of human BLC/BCA-1 is measured by its ability to chemoattract mouse BaF/3 cells transfected with human CXCR5.

Forme physique

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA containing 50 μg bovine serum albumin per 1 μg of cytokine.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H332 - H319

Classification des risques

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Consulter la Bibliothèque de documents

Julia Miriam Weiss et al.
Oncotarget, 7(7), 7550-7562 (2016-01-16)
Abnormal overexpression of CXCL13 is observed in many inflamed tissues and in particular in autoimmune diseases. Myasthenia gravis (MG) is a neuromuscular disease mainly mediated by anti-acetylcholine receptor autoantibodies. Thymic hyperplasia characterized by ectopic germinal centers (GCs) is a common
D F Legler et al.
The Journal of experimental medicine, 187(4), 655-660 (1998-03-28)
Although most leukocytes, T lymphocytes in particular, respond to several different chemokines, there is virtually no information on chemokine activities and chemokine receptors in B lymphocytes. A putative chemokine receptor, BLR1, that is expressed in Burkitt's lymphoma cells and B
R Förster et al.
Cell, 87(6), 1037-1047 (1996-12-13)
We describe the phenotype of gene-targeted mice lacking the putative chemokine receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a subpopulation of T helper cells. Blr1 mutant mice lack inguinal lymph nodes and possess
M D Gunn et al.
Nature, 391(6669), 799-803 (1998-03-05)
Secondary lymphoid organs (spleen, lymph nodes and Peyer's patches) are divided into compartments, such as B-cell zones (follicles) and T-cell zones, which provide specialized environments for specific steps of the immune response. Migration of lymphocyte subsets into these compartments is
Chunyan Li et al.
BioMed research international, 2015, 345413-345413 (2015-07-15)
To investigate the effect of CXCL13 (C-X-C motif chemokine 13) on hepatocellular carcinoma and clarify the potential mechanisms. 32 patients with hepatocellular carcinoma and 12 healthy controls were recruited for analyzing the expression of CXCL13 by RT-PCR (reverse transcription-polymerase chain
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