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Key Documents

171R-1

Sigma-Aldrich

CD71 (EP232) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

TFR1, TRF, TRFR, Transferrin Receptor 1, p90, transferrin receptor (p90, CD71)

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP232, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (171R-14)
vial of 0.1 mL concentrate Research Use Only (171R-14-RUO)
vial of 0.5 mL concentrate (171R-15)
vial of 1.0 mL concentrate (171R-16)
vial of 1.0 mL concentrate Research Use Only (171R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (171R-17-RUO)
vial of 1.0 mL predilute ready-to-use (171R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (171R-18-RUO)
vial of 7.0 mL predilute ready-to-use (171R-18)

Fabricant/nom de marque

Cell Marque

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

Isotype

IgG

Contrôle

bone marrow

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, membranous

Catégories apparentées

Description générale

Transferrin receptor 1 (CD71) is expressed on placental syncytiotrophoblasts, myocytes, basal keratinocytes, hepatocytes, endocrine pancreas, spermatocytes, and erythroid precursors. The level of transferrin receptor expression is highest in early erythroid precursors through the intermediate normoblast phase, after which expression decreases through the reticulocyte phase. The maturation of erythrocytes results in loss of transferrin receptor expression. AntiCD71 is useful in identifying erythroid precursors. The high level of transferrin receptor within erythroid precursors makes anti-CD71 an excellent marker for evaluation of erythroid precursors within bone marrow biopsy specimens and shows the following features: 1) distinct membranous and cytoplasmic staining pattern, which is easily recognized in bone marrow biopsy; 2) restriction to erythroid lineage within bone marrow biopsy specimens; 3) CD71 expression decreases with the maturation of erythrocytes, with the highest level seen in early forms and the lowest level in late normoblast stage, and most importantly; 4) mature erythrocytes do not express CD71.

Qualité

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Liaison

CD71 Positive Control Slides, Product No. 171S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Changes in cell surface antigen expression during hemopoietic differentiation.
Sieff C, Bicknell D, Caine G, et al.
Blood, 60(3), 703-713 (1982)
Expression of transferrin receptor on murine hematopoietic progenitors.
Lesley J, Hyman R, Schulte R, et al.
Cellular Immunology, 83(1), 14-25 (1984)
Cell surface antigen expression in human erythroid progenitors: erythroid and megakaryocytic markers.
Nakahata T and Okumura N
Leukemia & Lymphoma, 13(5-6), 401-409 (1994)
T Nakahata et al.
Leukemia & lymphoma, 13(5-6), 401-409 (1994-05-01)
This review summarizes the changes in cell surface antigen expression during proliferation and differentiation of human erythroid progenitors. The content is based on our experimental data obtained from complement-mediated cytotoxicity assays against hematopoietic progenitors and a combined technique of sequential
P Ponka et al.
The international journal of biochemistry & cell biology, 31(10), 1111-1137 (1999-12-03)
The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from transferrin involves the binding of transferrin to the transferrin receptor, internalization of transferrin

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