SMB01325

Albendazole sulfoxide

≥97% (HPLC)

• Synonyme(s) : Ricobendazole, Albendazole oxide, Albendazole sulfoxide, Methyl [5-(propane-1-sulfinyl)-1H-benzoimidazol-2-yl]-carbamate
• Formule empirique (notation de Hill): C₁₂H₁₅N₃O₃S
• Numéro CAS: 54029-12-8
• Poids moléculaire : 281.33
• Numéro Beilstein : 677664
• Numéro MDL: MFCD00797922
• Code UNSPSC : 12352119
• Nomenclature NACRES : NA.77

Propriétés

• Description: Modulation and Signaling
• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Couleur: white to beige
• Adéquation: HPTLC
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCS(=O)c1ccc2[nH]c(NC(=O)OC)nc2c1
• InChI: 1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• Clé InChI: VXTGHWHFYNYFFV-UHFFFAOYSA-N

Description

Description générale

Albendazole sulfoxide is a blood-brain barrier main metabolite of anti-parasitic agent albendazole that acts as a antihelminthic. It binds to colchicine binding site of β-tubulin and prevents polymerization. Albendazole sulfoxide exhibits greater affinity to parasitic β-tubulin than to mammalian.

Application

Metabolomics research

Actions biochimiques/physiologiques

Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G₂/M phase.

Autres remarques

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Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H317,H361d,H373,H410
• Conseils de prudence: P202 - P260 - P273 - P280 - P302 + P352 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Organes cibles: Adrenal gland,spleen,male reproductive organs,Blood
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable