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Key Documents

PHR1772

Supelco

Méropénème trihydraté

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Acide (1R,5S,6S)-2-[(3S,5S)-5-(diméthylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyéthyl]-1-méthylcarbapén-2-èm-3-carboxylique trihydraté

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About This Item

Formule empirique (notation de Hill):
C17H25N3O5S · 3H2O
Numéro CAS:
Poids moléculaire :
437.51
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

Agence

traceable to Ph. Eur. Y0001252
traceable to USP 1392454

Famille d'API

meropenem

CofA (certificat d'analyse)

current certificate can be downloaded

Conditionnement

pkg of 500 mg

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O

InChI

1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1

Clé InChI

CTUAQTBUVLKNDJ-OBZXMJSBSA-N

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Description générale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Meropenem belongs to the class of a semi-synthetic 1β-methylcarbapenem antibiotics. It shows an extremely broad-spectrum of antibacterial performance and is known for its high stability against renal dehydropeptidase-I (DHP-I).

Application

Lincomycin Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and peritoneal dialysis solution by spectrophotometric and various chromatography techniques.(58)
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

Le méropénème trihydraté est une bêta-lactamine à spectre ultra large présentant une activité antibiotique contre les bactéries à Gram positif et à Gram négatif.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB7853 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictogrammes

Health hazard

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Resp. Sens. 1 - Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

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Les clients ont également consulté

Stability of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution.
Tran MD, et al.
Journal of Pharmacy Practice and Research, 42(3), 218-222 (2012)
Ultraviolet spectrophotometry (dual wavelength and chemometric) and high performance liquid chromatography for simultaneous estimation of meropenem and sulbactam sodium in pharmaceutical dosage form.
Marwada KR, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 124(3), 292-299 (2014)
Chromatographic determination of polymerized impurities in meropenem.
Cai SY and Hu CQ
Journal of Pharmaceutical and Biomedical Analysis, 37(3), 585-589 (2005)
Youngchang Kim et al.
Protein science : a publication of the Protein Society, 29(3), 723-743 (2019-12-18)
Emergence of Enterobacteriaceae harboring metallo-β-lactamases (MBL) has raised global threats due to their broad antibiotic resistance profiles and the lack of effective inhibitors against them. We have been studied one of the emerging environmental MBL, the L1 from Stenotrophomonas maltophilia
Emily Marsh et al.
Clinica chimica acta; international journal of clinical chemistry, 486, 265-268 (2018-08-18)
Therapeutic drug monitoring is used for aminoglycosides and vancomycin, and has been proposed for β-lactam antibiotics. Clinical blood samples in the ICU are often obtained via an existing vascular catheter rather than fresh needle phlebotomy. If antibiotics had previously been

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