H5501

Méthyl 4-hydroxybenzoate, 4-hydroxybenzoate de méthyle

ReagentPlus^®, ≥99.0%, crystalline

• Synonyme(s) : Ester méthylique d’acide p-hydroxybenzoïque, NIPAGIN, Parahydroxybenzoate de méthyle
• Formule linéaire : HOC₆H₄CO₂CH₃
• Numéro CAS: 99-76-3
• Poids moléculaire : 152.15
• Numéro Beilstein : 509801
• Numéro CE : 202-785-7
• Numéro MDL: MFCD00002352
• Code UNSPSC : 51452201
• ID de substance PubChem : 329815219
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 200
• Gamme de produits: ReagentPlus^®
• Pureté: ≥99.0%
• Forme: crystalline
• Pf: 125-128 °C (lit.)
• Chaîne SMILES: COC(=O)c1ccc(O)cc1
• InChI: 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3
• Clé InChI: LXCFILQKKLGQFO-UHFFFAOYSA-N

Description

Application

Methyl 4-hydroxybenzoate has been used:

• in sex-linked recessive lethal (SLRL) test in Drosophila melanogaster
• as a constituent in cream formulation
• as an antifungal agent in Drosophila melanogaster culture

Actions biochimiques/physiologiques

Methyl 4-hydroxybenzoate, also called methyl paraben or nipagin, comprises the ester of p-hydroxybenzoic acid. It is present naturally in cloudberry, white wine and bourbon vanilla. Methyl 4-hydroxybenzoate has antimicrobial and antifungal functionality and is commercially used as a preservative in the food, cosmetic and pharmaceutical industry. Methyl 4-hydroxybenzoate has cytotoxic effects on keratinocytes in the presence of sunlight. Methyl 4-hydroxybenzoate upon solar irradiation mediates DNA damage and modulates esterase metabolism resulting in skin damage and favors cancer progression. Methyl 4-hydroxybenzoate has estrogenic functionality and upregulates estrogen-related genes.

Informations légales

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mentions de danger: H411
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Chronic 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 334.4 °F
• Point d'éclair (°C): 168 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves