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E0900000

Ergocalciferol

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Ergocalciférol, Ergostérol irradié, « Ergostérol irradié »

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About This Item

Formule empirique (notation de Hill):
C28H44O
Numéro CAS:
50-14-6
Poids moléculaire :
396.65
Numéro Beilstein :
1916682
Numéro MDL:
MFCD00166988
Code UNSPSC :
41116107
ID de substance PubChem :
329798871
Nomenclature NACRES :
NA.24

Source biologique

synthetic

Qualité

pharmaceutical primary standard

Agence

EP

Famille d'API

ergocalciferol

Forme

solid

Fabricant/nom de marque

EDQM

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Pf

114-118 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

−20°C

Chaîne SMILES 

CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1

Clé InChI

MECHNRXZTMCUDQ-RKHKHRCZSA-N

Informations sur le gène

human ... VDR(7421)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Ergocalciferol is a form of vitamin D, synthesized by some plants in the presence of UVB light. It can be obtained from diet intake or supplements.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301 + H311,H330,H372

Classification des risques

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Nutrition in the Prevention and Treatment of Disease (2008)
Simultaneous determination of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) in foods by selected reaction monitoring
Dimartino G
Journal of AOAC (Association of Official Analytical Chemists) International, 92(2), 511-517 (2002)
R Jorde et al.
European journal of endocrinology, 152(1), 39-45 (2005-03-15)
Smoking is associated with reduced bone density and calcium absorption, and reduced serum levels of vitamin D. A compensatory increase in serum parathyroid hormone (PTH) would therefore be expected as a result of an altered calcium balance. However, reports on
H A Bischoff-Ferrari et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 19(2), 265-269 (2004-02-19)
Intracellular 1,25-dihydroxyvitamin D receptor (VDR) is expressed in human skeletal muscle tissue. However, it is unknown whether VDR expression in vivo is related to age or vitamin D status, or whether VDR expression differs between skeletal muscle groups. We investigated
B L Salle et al.
The American journal of clinical nutrition, 71(5 Suppl), 1317S-1324S (2000-05-09)
During pregnancy, maternal serum concentrations of 25-hydroxyvitamin D, the circulating form of vitamin D, correlate with dietary vitamin D intake. Maternal serum concentrations of 1,25-dihydroxyvitamin D, the hormonal circulating and active form of vitamin D, are elevated during pregnancy; 1,25-dihydroxyvitamin
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Protocoles

AOAC Method 2011.11: UHPLC/MS/MS Analysis of Vitamin D2 and Vitamin D3 on Titan™ C18

Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

HPLC Analysis of Vitamin D2 and D3 on Ascentis® Express C18

This application demonstrates the suitability of the Ascentis Express C18, 5 μm, for the routine analysis of the fat-soluble vitamins D2 and D3 . Structures along with the optimized chromatogram obtained on the Ascentis Express C18, 5 μm are presented.

HPLC Analysis of Vitamin D2 and Vitamin D3 on Ascentis® C18

Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

HPLC Analysis of Fat-Soluble Vitamins on Ascentis® Express C18, Methanol Mobile Phase

Separation of Retinyl acetate, analytical standard; δ-Tocopherol, analytical standard; Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard; (±)-α-Tocopherol, analytical standard; Vitamin E acetate, analytical standard; Phylloquinone (K1), analytical standard; Retinol palmitate, analytical standard.

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