Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

Autres documents

D7439

Supelco

Dihydroartemisinin

analytical standard, mixture of α and β isomers

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C15H24O5
Poids moléculaire :
284.35
Numéro MDL:
MFCD28384156
Code UNSPSC :
41116107
ID de substance PubChem :
329798850
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

200

Pureté

≥97% (TLC)

Forme

powder

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C[C@H]1C(O)O[C@@]2([H])[C@@]3(OO4)[C@](CC[C@]4(C)O2)([H])[C@H](C)CC[C@]31[H]

InChI

1S/C15H24O5/c1-8-4-5-10-9(2)12(16)18-13-15(10)11(8)6-14(3,7-17-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12?,13+,14+,15+/m1/s1

Clé InChI

DJGUTYJDEZGRGH-NJEKVMANSA-N

Catégories apparentées

Description générale

Dihydroartemisinin is the major metabolite of the antimalarial agent, artemether. It is highly efficient against both drug-sensitive and drug-resistant strains of Plasmodium falciparum.
Antimalarial; antipsoriasis; anti-inflammatory.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Avertissement

Protect from light.

Notes préparatoires

artemisia plant extract

Pictogrammes

FlameEnvironment
GHS02,GHS09

Mention d'avertissement

Danger

Mentions de danger

H242 - H411

Classification des risques

Aquatic Chronic 2 - Org. Perox. C

Code de la classe de stockage

5.2 - Organic peroxides and self-reacting hazardous materials

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
SLCM2157
SLCK0307
SLCC9894
SLBT5645
SLBQ4595V

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 8

1 of 8

Artemether United States Pharmacopeia (USP) Reference Standard

USP

1042780

Artemether

USP

USP

1042850

Artesunate

Lumefantrine

Sigma-Aldrich

L5420

Lumefantrine

Tafenoquine succinate ≥95% (HPLC)

Sigma-Aldrich

SML0396

Tafenoquine succinate

Lumefantrine United States Pharmacopeia (USP) Reference Standard

USP

1370746

Lumefantrine

Amodiaquin dihydrochloride dihydrate analytical standard

Supelco

A2799

Amodiaquin dihydrochloride dihydrate

Pyriméthamine VETRANAL®, analytical standard

Supelco

46706

Pyriméthamine

Hypoxanthine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

H9636

Hypoxanthine

Anne Marijon et al.
Malaria journal, 13, 501-501 (2014-12-18)
Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-line treatment, but the lack of material and skills in the field
Zenglei Wang et al.
PloS one, 9(4), e93825-e93825 (2014-04-17)
Malaria elimination/eradication campaigns emphasize interruption of parasite transmission as a priority strategy. Screening for new drugs and vaccines against gametocytes is therefore urgently needed. However, current methods for sexual stage drug assays, usually performed by counting or via fluorescent markers
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection
Thomas GC, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 131-136 (1992)
Emily Caton et al.
Antimicrobial agents and chemotherapy, 63(11) (2019-08-28)
Antibacterial drugs are an important component of malaria therapy. We studied the interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against Plasmodium falciparum under static and dynamic conditions. In microtiter plate assays (static conditions), and as expected, parasites displayed the delayed
Anais Laleve et al.
Biochimica et biophysica acta. Molecular cell research, 1867(5), 118661-118661 (2020-01-29)
Artemisinin and its derivatives kill malaria parasites and inhibit the proliferation of cancer cells. In both processes, heme was shown to play a key role in artemisinin bioactivation. We found that artemisinin and clinical artemisinin derivatives are able to compensate
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique