909564

4-Azido-L-phenylalanine

≥98%

• Synonyme(s) : 3-(p-Azidophenyl)-L-alanine hydrochloride, 4-Azidophenylalanine hydrochloride, 4-N₃-L-Phenylalanine, p-Azido-L-phenylalanine hydrochloride, p-Azido-Phe*HCl, p-Azidophenylalanine hydrochloride, H-4-Azido-Phe*HCl, H-L-4-Azido-Phe-OH, H-L-Phe(4-N₃)-OH, H-Phe(4-N₃)*HCl, Phe(pN₃)*HCl
• Formule empirique (notation de Hill): C₉H₁₀N₄O₂
• Numéro CAS: 33173-53-4
• Poids moléculaire : 206.20
• Numéro MDL: MFCD00238100
• Code UNSPSC : 12352005

Propriétés

• Pureté: ≥98%
• Forme: powder
• Capacité de réaction: reaction type: click chemistry; reaction type: solution phase peptide synthesis
• Disponibilité: available only in USA
• Température de stockage: −20°C
• InChI: 1S/C9H10N4O2/c10-8(9(14)15)5-6-1-3-7(4-2-6)12-13-11/h1-4,8H,5,10H2,(H,14,15)/t8-/m0/s1
• Clé InChI: NEMHIKRLROONTL-QMMMGPOBSA-N

Description

Application

The in-vivo incorporation of clickable unnatural amino acids such as 4-Azido-L-phenylalanine with unique reactivity at a defined postition is used for functionalization of proteins. The azide functionalities in the protein can then be modified with almost any alkyne bearing molecule by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). Copper-free alternatives with strained internal alkynes are also available (SPAAC). Some examples enabled with this technique are protein PEGylation, masking with sugars, and the attachment to antibodies.

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable