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383376

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate

ACS reagent, ≥99%

Synonyme(s) :

Antimony potassium tartrate trihydrate, Tartar emetic

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About This Item

Formule empirique (notation de Hill):
C8H4K2O12Sb2 · 3H2O
Numéro CAS:
28300-74-5
Poids moléculaire :
667.87
Numéro CE :
234-293-3
Numéro MDL:
MFCD00167056
Code UNSPSC :
12352100
ID de substance PubChem :
24863959
Nomenclature NACRES :
NA.21

Qualité

ACS reagent

Niveau de qualité

200

Pureté

≥99%
99.0-103.0%

Forme

powder

Impuretés

≤0.020 meq/g Titr. acid or base

Perte

≤2.7% loss on drying

Pf

≥300 °C (lit.)

Solubilité

water: soluble

Traces de cations

As: ≤0.015%

Chaîne SMILES 

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

Clé InChI

WBTCZEPSIIFINA-UHFFFAOYSA-J

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Description générale

Potassium antimonyl tartrate trihydrate is a metalloid salt in which the antimony is in trivalent state (SbIII). Potassium antimonyl tartrate (PAT) is an antiparasitic agent predominantly used for treating infections caused by the parasite Leishmania. Its antiangiogenic and antitumor properties has been investigated in nonsmall-cell lung cancer (NSCLC) cells. Studies in Chinese hamster ovary cells show that it may prevent the repair of DNA double strand breaks (DSBs) caused by γ-irradiation.

Application

Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199.
Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). It may also be employed in the spectrophotometric determination of total phosphorus in dry sediments.

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H315,H317,H332,H411

Classification des risques

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCQ4512
MKCQ0076
MKCP8052
MKCN4924
MKCG7629

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v
Vijayaraghavan K and Balasubramanian R.
Industrial & Engineering Chemistry Research, 50(17), 9864-9869 (2011)
Reduced Antimony Accumulation in ARM58-Overexpressing Leishmania infantum.
Schafer C, et al.
Antimicrobial Agents and Chemotherapy, 58(3), 1565-1574 (2014)
Nutrient contents in bottom sediment samples from a southern Brazilian microbasin.
Antunes M, et al.
Environmental earth sciences, 69(3), 959-968 (2013)
Susan Wyllie et al.
Biochemical pharmacology, 71(3), 257-267 (2005-12-02)
Trivalent antimonial compounds (Sb(III)), originally used in the treatment of leishmaniasis, are now being proposed as a novel therapy for acute promyelocytic leukaemia (APL). Here, we examine the effects of Sb(III) and pentavalent antimonial drugs (Sb(V)) on glutathione homeostasis, oxidative
G Sudhandiran et al.
The Journal of biological chemistry, 278(27), 25120-25132 (2003-04-23)
The capability of the obligate intracellular parasites like Leishmania donovani to survive within the host cell parasitophorous vacuoles as nonmotile amastigotes determines disease pathogenesis, but the mechanism of elimination of the parasites from these vacuoles are not well understood. By
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